Michael Sheen and Lizzy Caplan !
He will play William Masters, she will play Virginia Johnson. They are considered "human sexuality pioneers", and this series by Michelle Ashford (The Pacific) would be based upon Thomas Maier's book, The life and times of William Masters and Virginia Johnson, the couple who taught America how to love".
Michael Sheen's previous TV credits include a recurring guest spot on 30 Rock season 4 and his portrayal of Tony Blair in two TV movies written by Peter Morgan : The Deal (2003) on the BBC and The Special Relationship (2010) on HBO — he also played the former prime minister in the feature movie The Queen (2006), also written by Peter Morgan. Paul Bettany walked out of the role of William Masters a few weeks ago.
Lizzy Caplan's previous TV credits include appearances on Freaks and Geeks and season 1 of True Blood, and leading roles in The Class and also in the brilliant comedy Party Down. She's currently playing a recurring role on New Girl.
John Madden (Shakespeare in Love) will shoot a pilot for Masters of Sex next March in New York. Showtime will then decide if they pick it up to series. The other pilot in development at Showtime is Ray Donovan, starring Liev Schreiber.
Source : Hitfix.
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